Pall Allegro 2D Biocontainer with AdvantaFlex Tubing 100 ml System

Description

Pall Allegro 650-202E 2D Biocontainer – 100 mL, AdvantaFlex Tubing, Sterile

The Pall Allegro 650-202E is a premium, single-use 2D biocontainer engineered for the secure storage, transfer, and sampling of high-value biopharmaceutical fluids. Designed as a 100 mL flat “pillow” bag, it is manufactured from Pall’s proprietary ultra-low extractable film, ensuring exceptional clarity and absolute product integrity. This specific configuration is pre-plumbed with weldable AdvantaFlex tubing, providing a seamless, aseptic integration into automated bioprocessing skids, bioreactors, and downstream purification lines. Pre-sterilized via gamma irradiation, this ready-to-use closed system is an essential component for GMP-compliant cell culture feeding, sterile sampling, and small-volume seed train expansions.

Technical Performance and Design

• AdvantaFlex TPE Tubing: Provides exceptional weldability and sealability, allowing for secure, sterile connections and disconnections using standard tube welding equipment without compromising the closed sterile envelope.

• High-Purity Biocontainer Film: Constructed from a highly transparent, low-binding polymer film that generates virtually zero extractables and leachables, protecting sensitive proteins, viral vectors, and monoclonal antibodies (mAbs).

• Optimized 2D Pillow Design: The flat, low-profile geometry maximizes the surface-area-to-volume ratio, facilitating rapid and uniform temperature transfer during the freezing and thawing of critical biological materials.

• Robust Seal Integrity: Advanced RF welding technology ensures that the perimeter seams and tubing port junctions can comfortably withstand the rigors of high-pressure fluid transfers and cryogenic storage environments.

Product Specifications

• Catalog Number: 650-202E

• Product Line: Allegro 2D Biocontainers

• Maximum Volume: 100 mL

• Bag Style: 2D Pillow Bag

• Tubing Type: AdvantaFlex (Thermoplastic Elastomer)

• Sterility: Single-Use, Pre-sterilized (Gamma Irradiated)

Key Benefits & Applications

• Aseptic Sampling: The 100 mL capacity makes it the ideal sterile vessel for pulling representative quality control (QC) samples directly from large-scale bioreactors or formulation tanks.

• Plug-and-Play Integration: The AdvantaFlex lines completely eliminate the need for mechanical Luer locks or sanitary flanges, significantly reducing the risk of accidental disconnects, cross-contamination, and leaks.

• Process Scalability: Utilizes the exact same fluid contact materials as large-scale 50-liter and 200-liter Allegro bags, ensuring reliable, consistent validation data from R&D scale-up to commercial manufacturing.

• Eliminates Cleaning Validation: As a completely closed, single-use system, it bypasses the massive pure water and labor requirements associated with traditional stainless steel Clean-in-Place (CIP) and Sterilize-in-Place (SIP) processes.

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