Charter Medical Biocube 4L with Clear Pak Film

Description

Charter Medical BioCube Single-Use Flexible Bio-Container – 4 L Volume, Clear-Pak Multi-Layer Film, Self-Supporting Aseptic Storage Design (MPN: CML-BIOCUBE-4L)

The Charter Medical CML-BIOCUBE-4L is a premium, bioprocess-grade single-use flexible container engineered for the secure handling, transport, and cold archiving of critical process fluids, cell culture media, and downstream biopharmaceutical intermediates. Featuring a specialized self-supporting dimensional geometry, this 4 Liter flexible liner bag expands into a stable, freestanding footprint during fluid filling, entirely removing the need for rigid secondary outer support buckets. Fabricated from proprietary Clear-Pak multi-layer co-extruded film, the container pairs an inert Ultra-Low Density Polyethylene (ULDPE) contact layer with an Ethylene Vinyl Alcohol (EVOH) gas barrier layer. This matrix provides exceptional optical clarity, structural tear strength, and protection against gas transmission while functioning flawlessly across an extensive cryogenic temperature range.

Technical Performance and Design

• Freestanding BioCube Architecture: Developed with an innovative physical structure that expands into a self-supporting cube as fluid fills the cavity. This design simplifies handling on laminar flow hoods, saves bench space, and optimizes storage density inside deep freezers and cold storage vaults.

• Clear-Pak Multi-Layer Co-Extruded Film: Formulated with a high-performance single web film system consisting of an outer Polyethylene (PE) durability shell, an intermediate EVOH gas barrier layer, and an ultra-pure ULDPE fluid contact liner. This multi-layer approach ensures superior flexibility and mechanical puncture resistance.

• Advanced EVOH Gas Barrier Layer: Incorporates an Ethylene Vinyl Alcohol (EVOH) core barrier that restricts oxygen and carbon dioxide transmission. This feature prevents pH drift and oxidation, safeguarding the chemical stability of sensitive biological reagents and cell culture medias over long storage periods.

• Extensive Cryogenic Operating Horizon: The specialized polymer matrix retains its physical pliability and impact strength without fracturing or embrittlement across a wide thermal operating range, safely weathering deep frozen archiving down to minus 80°C (-80°C).

Product Specifications

• Catalog Number / MPN: CML-BIOCUBE-4L (BioCube Series)

• Manufacturer / Brand: Charter Medical, Ltd.

• Nominal Storage Capacity: 4 Liters (4L)

• Film Technology Substrate: Clear-Pak Co-Extruded Polymer (13 mil / 330 micron thickness)

• Fluid Contact Material: Ultra-Low Density Polyethylene (ULDPE) — Animal Derivative Component Free (ADCF)

• Gas Barrier Efficiency: Oxygen transmission rate of less than 0.003 mL/100 sq. in./day/atm

• Thermal Endurance Window: Rated for safe physical operation from minus 80°C up to plus 50°C

• Regulatory Compliance Standards: USP Class VI Biocompatibility Pass, USP <87> Cytotoxicity Pass, USP <85> Bacterial Endotoxin Pass, and ISO 13485 certified cleanroom manufacturing

• Standard Case Configuration: Shipped wholesale as a case of 20 individual bio-container assemblies

Key Benefits and Applications

• Biopharma Media and Buffer Storage: The single-use cleanroom choice for holding sterile fluid lots, intermediate cell harvest fractions, purification buffers, and process reagents without cross-contamination risks.

• Aseptic Media Fill Applications: Deployed alongside large-scale cell expansion loops and bioreactor networks to manage process fluids during sterile scale-up workflows.

• Optical Process Clarity: Features a 97 percent clarity and 93 percent light transmittance rating, allowing technicians to easily perform visual inspections for color changes, particulate matter, or precipitate formation.

• Eliminated Cleaning Validation Costs: The disposable, single-use format removes the need for capital-intensive Clean-in-Place (CIP) and Steam-in-Place (SIP) validation cycles, reducing turnaround times between production batches.

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