Description
Description
Guanidine Hydrochloride Organic Base ≥99% Titration 2 Kg
Synonym: Aminoformamidine hydrochloride, Aminomethanamidine hydrochloride, Guanidinium chloride
- CAS Number 50-01-1
- Linear Formula NH2C(=NH)NH2 · HCl
- Molecular Weight 95.53
- Beilstein/REAXYS Number 3591990
- EC Number 200-002-3
- MDL number MFCD00013026
- PubChem Substance ID 24895176
| assay | ≥99% (titration) |
| pH | (25 °C, 4.6 – 6 at 573 g/L) |
| mp | 180-185 °C (lit.) |
| solubility | H2O: 6 M |
| absorption | ≤0.10 at 260 nm in H2O at 6 M |
| SMILES string | Cl[H].NC(N)=N |
| InChI | 1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H |
| InChI key | PJJJBBJSCAKJQF-UHFFFAOYSA-N |
Application
Guanidine hydrochloride is used in RNA isolation to dissociate nucleoproteins and inhibit RNase.
Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.
GHS07
Signal word Warning
Hazard statements H302 + H332-H315-H319
Precautionary statements P261-P301 + P312 + P330-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS MF4300000
Documents
Safety Data Sheet
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