Kimble Tissue Homogenizer 1.5 ml Closed System Disposable Case of 50

Description

Kimble BioMasher II Closed System Micro Tissue Grinder – 1.5 mL, Polypropylene/Polyacetal, Sterile, Individually Wrapped (MPN: 749625-0030)

The Kimble 749625-0030 (manufactured under DWK Life Sciences) is a premium, sterile, micro-sized closed system tissue homogenizer engineered for the safe disruption and extraction of cellular components from small biological specimens. Comprising a clear polypropylene microcentrifuge-style tube paired with a rugged polyacetal pestle, this single-use tool operates via a combination of mechanical shearing and high-compression forces. Designed as a fully closed system, it utilizes a molded-in shaft guard on the pestle that physically isolates sample splashes, protecting lab technicians from exposure to hazardous, infectious, or radioactive aerosols while eliminating well-to-well cross-contamination during nucleic acid or protein extractions.

Technical Performance and Design

• Abrasive Contact Geometry: The tip of the polyacetal pestle and the matching interior base of the 1.5 mL tube feature highly controlled, precision-molded abrasive surfaces. This texture cross-links the sample during manual rotation, accelerating the cellular rupture of tough, fibrous matrices.

• Molded-In Shaft Guard: Features an integrated plastic shield on the pestle handle that acts as a tight splash canopy over the tube orifice. This prevents sample tracking up the shaft or venting outside the tube, protecting the technician’s gloves and surrounding workspace.

• Shear & Compression Extraction: Forcing the pestle downward compresses tissue cells within a micro-clearance window ($0.002text{ to }0.003text{ inches}$), forcing cell boundaries to rupture. Pulling the pestle back creates a slight vacuum that returns the sample into the grinding zone for an additional homogenization stroke.

• Individually Wrapped Sterility: Arrives gamma-sterilized and individually sealed in a clear medical-grade peel-pouch, ensuring the hardware remains free of environmental RNase, DNase, or foreign DNA until the exact moment of specimen introduction.

Product Specifications

• Catalog Number / MPN: 749625-0030 (7496250030)

• Manufacturer / Brand: DWK Life Sciences / Kimble® BioMasher II®

• Volumetric Capacity: 1.5 mL

• Tube Material: Clear Medical-Grade Polypropylene (PP)

• Pestle Material: High-Rigidity Polyacetal (POM)

• Sterility Status: Gamma Irradiated Sterile

• Packaging Configuration: Case of 50 Units (Individually Wrapped Pouches)

Key Benefits & Applications

• ADME & Preclinical Biopsies: The baseline clinical standard for disrupting small organ biopsies (liver, kidney, spleen) or tumor xenografts for downstream target analyte validation.

• Genomics & RNA Extraction: The closed system design completely restricts aerosolized amplicon or target RNA tracking, maximizing structural isolation yields when separating fragile mRNA/tRNA from animal tissues, insects, or plant structures.

• Zero Clean-Up Overhead: Because the system is entirely disposable, it completely removes the high laboratory labor cost and hazardous waste streams linked to washing and autoclaving traditional glass Potter-Elvehjem tissue grinders.

• Proteomics & Enzyme Harvests: The inert plastic matrix is formulated without slipping chemicals or mold release trace matrices, safeguarding delicate enzyme chains or mass spectrometry analytes from analytical line interference.

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