Description
Description
Factor VIII Related Antigen; Polyclonal (Ready-To-Use), 2 mL.
- Species: Rabbit Polyclonal
- Clone: Polyclonal MW: 270 kD
- Species Reactivity: Human
- Positive Control: Blood vessels in skin or intestine
Specificity: Recognizes a multimeric glycoprotein of 270kDa, identified as factor VIII related antigen or von Willebrand factor. This protein has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. Von Willebrand factor is synthesized by endothelial cells and stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII. ScyTek’s antibody reacts specifically with the endothelial cells of normal, reactive, and neoplastic blood and lymphatic vessels and shows a finely granular cytoplasmic staining. It also reacts with endocardium, platelets and megakaryocytes. Von Willebrand factor is one of the most useful markers to identify endothelial (or megakaryocytic) lineage of neoplasms. However, because not all endothelial cells synthesize (or store) this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant.
- Volume: 2 mL
- Storage: 2°C- 8°C
- Download: Instructions For Use
- MSDS: Material Safety Data Sheet
Antibodies> Polyclonal Ready-to-Use
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Terms & Conditions
These chemicals are for professional manufacturing, research laboratories and industrial / commercial usage only. Not for medical or consumer use. We currently cannot ship this product to doctor offices, pharmacies, medical facilities, veterinarians or residences. All orders are verified prior to shipment. Orders shipping to consumers or medical facilities will be canceled.
Please note: This product is not returnable. Chemicals cannot be expedited.
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