WaterSep Hollow Fiber Filter Cartridge Discover12

Description

WaterSep Green Line Discover12 Hollow Fiber Cartridge – 0.1 µm, 1.0 mm ID (SU 910 10DIS12 LL)

The WaterSep SU 910 10DIS12 LL is a high-performance, single-use Tangential Flow Filtration (TFF) module designed for small-scale microfiltration, clarification, and cell harvest applications. Part of the Discover12 Green Line, this cartridge is engineered to be a fully disposable, “plug-and-play” solution that eliminates the need for cleaning validation and autoclaving. It features a 0.1 µm modified Polyethersulfone (m-PES) membrane, which provides high flux and low protein binding for maximum product yield. With a 1.0 mm lumen ID, this hollow fiber cartridge offers an “open channel” design that is highly resistant to fouling and clogging, making it ideal for processing high-density cell cultures, fermentation broths, and viscous biological fluids.

Technical Performance and Design

• 0.1 µm Microfiltration Membrane: Specifically sized for the retention of whole cells and large cellular debris while allowing proteins and smaller viral particles to pass freely into the permeate.

• Anti-Fouling m-PES Chemistry: The proprietary modified Polyethersulfone membrane is inherently low-binding and humectant-free, requiring no pre-rinse or flushing before use, which significantly reduces preparation time.

• 1.0 mm Lumen Diameter: The wide-channel geometry provides low-shear processing and accommodates high-solids feeds, ensuring consistent flow rates and protecting sensitive cell viability during perfusion or harvest.

• Discover12 Scale Efficiency: Optimized for laboratory-scale processing of volumes ranging from 100 mL up to 2 Liters, providing a seamless scale-up path to larger Investigator and BioProducer modules.

Product Specifications

• Catalog Number: SU 910 10DIS12 LL

• Pore Size: 0.1 µm

• Lumen ID: 1.0 mm

• Surface Area: 52 cm²

• Connectors: Luer Lock (Feed/Retentate and Permeate Ports)

• Membrane Material: Modified Polyethersulfone (m-PES)

• Sterility: Gamma Irradiated / Ready-to-Use

Key Benefits & Applications

• Cell Harvest & Clarification: The industry standard for the primary recovery of mammalian (CHO), insect, and bacterial (E. coli) cell cultures.

• Single-Use (Green Line) Workflow: Eliminates cross-contamination risks and the heavy water (WFI) usage associated with cleaning and validating reusable TFF systems.

• Viral Vector Purification: Often utilized in AAV and Lentivirus workflows for initial clarification steps where maintaining high product transmission is critical.

• Low Shear Force: Gentle hollow fiber fluid dynamics preserve delicate cells, making it a superior choice over flat-sheet cassettes for shear-sensitive biological products.

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