Natrix NatriFlo HD-Q Pilot Membrane Filter Sealed NXF-10

Description

Natrix NXF-10 NatriFlo HD-Q Pilot Membrane Filter – High Productivity Q-Chromatography

The Natrix NXF-10 is a pilot-scale membrane chromatography module designed for high-productivity downstream purification. Featuring Natrix HD-Q technology, this module utilizes a high-density quaternary amine (strong anion exchange) functionalized hydrogel within a macroporous membrane matrix. This unique architecture combines the high binding capacity typical of resin-based chromatography with the high flow rates of membrane filtration. The NXF-10 is specifically optimized for “flow-through” applications, providing exceptional removal of DNA, host cell proteins (HCP), and viral contaminants in a single pass. Designed for pilot-scale operations, it provides linear scalability for biopharmaceutical manufacturers transitioning from laboratory development to full-scale production.

Technical Performance and Design

• HD-Q Membrane Technology: The high-density Quaternary Amine chemistry provides superior binding capacity for negatively charged impurities, even at high conductivity and high flow rates.

• Macroporous Hydrogel Matrix: Unlike traditional beads, the hydrogel structure allows for rapid mass transfer and convective flow, significantly reducing processing times and buffer consumption.

• Exceptional Impurity Clearance: Validated for the highly efficient removal of genomic DNA, acidic proteins, and viruses (e.g., MVM, MuLV), ensuring the highest standards of drug substance purity.

• Pilot-Scale Efficiency: The NXF-10 format is engineered to handle mid-sized batches, offering a robust and reliable platform for process validation and scale-up studies.

Product Specifications

• Catalog Number: NXF-10

• Chemistry: HD-Q (Strong Anion Exchange / Quaternary Amine)

• Device Format: NatriFlo Pilot Module

• Membrane Volume: Approx. 10 mL (Internal Matrix)

• Recommended Mode: Negative Mode / Flow-Through Chromatography

• Connections: Standard Sanitary Flange (TC) for secure integration with pilot-scale chromatography systems.

Key Benefits & Applications

• Polishing Chromatography: The industry-standard tool for the final “polishing” step in monoclonal antibody (mAb) and recombinant protein purification workflows.

• Viral Clearance: Serves as a critical orthogonal step for viral safety, providing high Log Reduction Values (LRV) for both enveloped and non-enveloped viruses.

• Reduced Footprint: The high productivity of the HD-Q membrane allows for a smaller hardware footprint and lower capital expenditure compared to traditional Q-resin columns.

• Scalable Process Solution: Part of the NatriFlo family, ensuring a seamless transition from the NXF-Mini laboratory scale to production-scale Natrix modules.

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